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Render Timestamp: 2024-10-11T10:06:44.896Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-19 21:57:42.641
Product last modified at: 2024-09-19T22:12:53.836Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

LY-364947 #54678

    Product Information

    Product Usage Information

    LY-364947 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.22 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 272.3 g/mol
    Purity >98%
    Molecular Formula C17H12N4
    CAS 396129-53-6
    Solubility Soluble in DMSO at 25 mg/ml.

    Background

    LY-364947, also known as HTS-466284, is a potent and selective TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) inhibitor. This small molecule specifically targets TGF-β RI with an IC50 value of 59 nM and is less effective on TGF-β RII and MLK-7K (IC50 values of 400 nM and 1400 nM, respectively) (1). LY-364947 regulates MDA-MB-231 cell invasion by inhibiting autocrine TGF-β signaling (2). Patients in intensive care units (ICUs) that suffer from chronic sepsis can experience weakening of the diaphragm muscles caused by muscle wasting, requiring mechanical ventilation. Members of the TGF-β family can trigger the activation of protein breakdown. Inhibition of the TGF-β pathway can protect the diaphragm during chronic sepsis, making LY-364947 an interesting compound to study as it relates to effective ICU patient care (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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