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MLN4924 (Pevonedistat)
Activators & Inhibitors
Chemical Modulators

MLN4924 (Pevonedistat) #85923

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MLN4924 (Pevonedistat): Image 1
Western blot analysis of extracts from K-562 cells, untreated (-) or treated with MLN4924 (Pevonedistat) (300 nM, 24 hr; +), using NEDD8 (19E3) Rabbit mAb #2754 (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower).
MLN4924 (Pevonedistat): Image 2
Chemical structure of MLN4924 (Pevonedistat).

Product Usage Information

MLN4924 (Pevonedistat) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 1 mg of powder in 451.2 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 443.2 g/mol
Purity >98%
Molecular Formula C21H25N5O4S
CAS 905579-51-3
Solubility Soluble in DMSO at 10 mg/ml.


MLN4924 (Pevonedistat) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) (1). The NAE is part of the NEDD8 conjugation pathway that involves the ubiquitin-like NEDD8 protein and cullin-RING ligases (CRL). The NAE is responsible for the covalent attachment of NEDD8 to cullin proteins, termed neddylation, resulting in a conformational change within the CRL, analogous to ubiquitination. This is a reversible, multi-step process responsible for cell cycle progression and survival pathways in cancer cells (2). The inhibition of NAE by MLN4924 (Pevonedistat) induces apoptosis in human tumor cells and reduces human tumor xenograft growth in mice (IC50 = 4.7 nM) (1-3).
  1. Soucy, T.A. et al. (2009) Nature 458, 732-6.
  2. Soucy, T.A. et al. (2010) Genes Cancer 1, 708-16.
  3. Wang, M. et al. (2011) Expert Opin Ther Targets 15, 253-64.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
To Purchase # 85923
Cat. # Size Qty. Price
1 mg
$ 68