MS1943 #23943
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 718.9 g/mol |
| Purity | |
| Molecular Formula | C42H54N8O3 |
| CAS | 2225938-17-8 |
| Solubility | Soluble in DMSO at 10 mg/mL. |
Background
MS1943 is an Ezh2 degrader that lowers levels of Ezh2 protein in cells (7). Ezh2 degradation has proven to be effective beyond traditional methyltransferase inhibitors in certain cancers that grow independent of Ezh2 catalytic activity (7,8).
- Sellers, W.R. and Loda, M. (2002) Cancer Cell 2, 349-50.
- Visser, H.P. et al. (2001) Br J Haematol 112, 950-8.
- Chen, H. et al. (1996) Genomics 38, 30-7.
- Tonini, T. et al. (2004) Oncogene 23, 4930-7.
- Müller, J. et al. (2002) Cell 111, 197-208.
- Kleer, C.G. et al. (2003) Proc Natl Acad Sci USA 100, 11606-11.
- Ma, A. et al. (2020) Nat Chem Biol 16, 214-222.
- Jeong, Y. et al. (2023) Front Oncol 13, 1252658.
Limited Uses
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