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38695
Nafamostat Mesylate
Activators & Inhibitors
Chemical Modulators

Nafamostat Mesylate #38695

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Chemical structure of Nafamostat Mesylate.

Product Usage Information

Nafamostat Mesylate is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.23 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at 4ºC and use within 1 month or at -80ºC and use within 6 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 539.6 g/mol

Purity: >98%

Molecular Formula: C19H17N5O2 • 2CH3SO3H

CAS: 82956-11-4

Solubility: Soluble in DMSO at 50 mg/ml or water at 50 mg/ml.

Background

Nafamostat Mesylate, also known as FUT-175, is a potent and reversible, broad-spectrum serine protease inhibitor of trypsin (Ki = 15 nM), tryptase (Ki = 95.3 pM), and other additional proteases (1). This small compound has been identified as a key player in the disruption of the inflammatory response via inhibition of the complement system and coagulation cascade (2). Its wide range of inhibitory activity displays anti-cancer and anti-viral properties and has shown effective inhibition of MERS-CoV by preventing membrane fusion, making it a promising therapeutic candidate against the 2019-nCoV infection (EC50 = 22.50 μM) (3,4).

  1. Mori, S. et al. (2003) J Pharmacol Sci 92, 420-3.
  2. Aoyama, T. et al. (1984) Jpn J Pharmacol 35, 203-27.
  3. Chen, X. et al. (2019) Front Oncol 9, 852.
  4. Wang, M. et al. (2020) Cell Res 30, 269-71.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 38695S
Product # Size Price
38695S
10 mg $ 75