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Render Timestamp: 2025-02-14T11:04:28.955Z
Commit: 7500bcdc731e9059bbdfbdbe9e72caa896e426e8
XML generation date: 2024-09-19 21:57:41.856
Product last modified at: 2025-01-01T09:00:45.355Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Olaparib (AZD2281) #93852

    Product Information

    Product Usage Information

    Olaparib (AZD2281) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 434.5 g/mol
    Purity >98%
    Molecular Formula C24H23FN4O3
    CAS 763113-22-0
    Solubility Soluble in DMSO at 33 mg/ml or ethanol at 1.7 mg/ml.

    Background

    Olaparib (AZD2281) is a potent and selective PARP-inhibitor, specifically targeting PARP1 and PARP2 (IC50 = 5 nM and 1 nM, respectively) (1). This small molecule has synergistic effects on breast cancer cell lines when combined with other treatments, independent of BRCA1 status (2). Non-small cell lung cancer (NSCLC) cancer cells that are homologous recombination (HR)-deficient are hypersensitive to Olaparib (AZD2281) treatment, resulting in reduced cell viability (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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