PD184352 #12147

Inquiry Info. # 12147

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Product Information

Product Usage Information

PD184352 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1044.6 µl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 0.1-10 µM for 0.5-1 hr prior to treating with a stimulator or is used alone with varying treatment times lasting up to 24 hr. Soluble in DMSO at 25 mg/ml and ethanol at 8 mg/ml with warming; poorly soluble in water with maximum solubility in water at ~5-10 µM.

Storage

Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	478.66 g/mol
Purity	>99%
Molecular Formula	C₁₇H₁₄ClF₂IN₂O₂₂
CAS	212631-79-3
Solubility	Soluble in DMSO at 50mg/ml and EtOH at 8.3mg/ml.

Background

PD184352 (CI-1040) is a highly potent and selective noncompetitive MEK inhibitor with an IC₅₀ of 17 nM for MEK1 (1). Treatment of cells with PD184352 leads to suppression of MAPK activation (1-4) and potently inhibits the proliferation of cells harboring the B-Raf mutation V600E (2,3). Researchers have shown that PD184352 effectively inhibits MEK5, although not as potently as MEK1 (4).

Alternate Names

CI-1040; MAPK; MEK inhibitor; MEK1; MEK5

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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