Poly(dA:dT) Sodium Salt #47945
Product Information
Product Usage Information
Poly(dA:dT) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Background
Poly(dA:dT) Sodium Salt, also known as poly(deoxyadenylic-thymidylic) acid sodium salt, is a double-stranded alternating copolymer DNA model with repetitive synthetic sequences of poly(dA-dT):poly(dT-dA). Poly(dA:dT) Sodium Salt plays a role in the innate immune response by binding to pattern recognition receptors (PRRs), which are used by host cells to detect pathogen-associated molecular patterns (PAMPs) (1). This synthetic B-DNA analog can trigger intracellular DNA sensors, such as DDX41, that leads to stimulator of interferon genes (STING) activation, and downstream activation of the transcription factors NF-κB and IRF-3 (2,3). The effect of cytosolic DNA on the innate immune response is particularly important when studying viral infections (1-3).
Limited Uses
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