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PDP - Template Name: Chemical Modulators
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Poly(dA:dT) Sodium Salt #47945

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    Product Information

    Product Usage Information

    Poly(dA:dT) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze/thaw cycles.

    Background

    Poly(dA:dT) Sodium Salt, also known as poly(deoxyadenylic-thymidylic) acid sodium salt, is a double-stranded alternating copolymer DNA model with repetitive synthetic sequences of poly(dA-dT):poly(dT-dA). Poly(dA:dT) Sodium Salt plays a role in the innate immune response by binding to pattern recognition receptors (PRRs), which are used by host cells to detect pathogen-associated molecular patterns (PAMPs) (1). This synthetic B-DNA analog can trigger intracellular DNA sensors, such as DDX41, that leads to stimulator of interferon genes (STING) activation, and downstream activation of the transcription factors NF-κB and IRF-3 (2,3). The effect of cytosolic DNA on the innate immune response is particularly important when studying viral infections (1-3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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