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Poly(dA:dT) Sodium Salt
Activators & Inhibitors
Chemical Modulators

Poly(dA:dT) Sodium Salt #47945

Citations (0)
Western blot analysis of extracts from THP-1 cells differentiated with TPA (12-O-Tetradecanoylphorbol-13-Acetate) #4174 (80 nM, 18 hr) and then untransfected (-) or transfected with Poly(dA:dT) Sodium Salt (5 μg/mL, 3 hr; +), using Phospho-STING (Ser366) (D7C3S) Rabbit mAb #19781 (upper), STING (D2P2F) Rabbit mAb #13647 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Product Usage Information

Poly(dA:dT) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze/thaw cycles.


Poly(dA:dT) Sodium Salt, also known as poly(deoxyadenylic-thymidylic) acid sodium salt, is a double-stranded alternating copolymer DNA model with repetitive synthetic sequences of poly(dA-dT):poly(dT-dA). Poly(dA:dT) Sodium Salt plays a role in the innate immune response by binding to pattern recognition receptors (PRRs), which are used by host cells to detect pathogen-associated molecular patterns (PAMPs) (1). This synthetic B-DNA analog can trigger intracellular DNA sensors, such as DDX41, that leads to stimulator of interferon genes (STING) activation, and downstream activation of the transcription factors NF-κB and IRF-3 (2,3). The effect of cytosolic DNA on the innate immune response is particularly important when studying viral infections (1-3).

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.
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