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Render Timestamp: 2025-03-19T11:00:37.681Z
Commit: 779953b12a5930618aae6aca7c87fb286faeb1d7
XML generation date: 2025-03-07 13:15:30.220
Product last modified at: 2025-03-06T16:45:09.878Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Poly(I:C) Sodium Salt #61401

    Product Information

    Product Usage Information

    Poly(I:C) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Purity >98%
    CAS 42424-50-0
    Solubility Soluble in water at 10 mg/ml with warming.

    Background

    Poly(I:C) Sodium Salt, also known as polyinosinic-polycytidylic acid sodium salt, is a synthetic analog to double-stranded RNA (dsRNA) and potent activator of Toll-like receptor 3 (TLR3). The Toll-like receptor (TLR) family plays an important role in the innate immune response (1). TLR3 functions as a receptor for dsRNA typically associated with viral infection (2). Binding of dsRNA, or the analog Poly(I:C), to TLR3 triggers activation of transcription factors NF-κB and IRF3 through the adaptor protein TICAM-1/TRIF (3,4). Studies have shown that combination treatment with Poly(I:C) can increase vaccine immunogenicity against viral and cancerous diseases (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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