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Poly(I:C) Sodium Salt
Activators & Inhibitors
Chemical Modulators

Poly(I:C) Sodium Salt #61401

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Poly(I:C) Sodium Salt: Image 1
Western blot analysis of extracts from THP-1 cells differentiated with TPA (12-O-Tetradecanoylphorbol-13-Acetate) #4174 (80 nM, 18 hr) and then untransfected (-) or transfected with Poly(I:C) Sodium Salt (5 μg/ml, 6 hr; +), using Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb #4947 (upper), IRF-3 (D6I4C) XP® Rabbit mAb #11904 (middle), or β-Tubulin (D2N5G) Rabbit mAb #15115 (lower).

Product Usage Information

Poly(I:C) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Purity >98%
CAS 42424-50-0
Solubility Soluble in water at 10 mg/ml with warming.


Poly(I:C) Sodium Salt, also known as polyinosinic-polycytidylic acid sodium salt, is a synthetic analog to double-stranded RNA (dsRNA) and potent activator of Toll-like receptor 3 (TLR3). The Toll-like receptor (TLR) family plays an important role in the innate immune response (1). TLR3 functions as a receptor for dsRNA typically associated with viral infection (2). Binding of dsRNA, or the analog Poly(I:C), to TLR3 triggers activation of transcription factors NF-κB and IRF3 through the adaptor protein TICAM-1/TRIF (3,4). Studies have shown that combination treatment with Poly(I:C) can increase vaccine immunogenicity against viral and cancerous diseases (5,6).
  1. Alexopoulou, L. et al. (2001) Nature 413, 732-8.
  2. Medzhitov, R. et al. (1997) Nature 388, 394-7.
  3. Horng, T. et al. (2001) Nat Immunol 2, 835-41.
  4. Oshiumi, H. et al. (2003) Nat Immunol 4, 161-7.
  5. Liu, C. et al. (2018) Hum Vaccin Immunother 14, 931-40.
  6. Zhou, C.X. et al. (2014) BMC Vet Res 10, 2.

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 61401
Cat. # Size Qty. Price
25 mg
$ 215