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65085
Ribavirin
Activators & Inhibitors
Chemical Modulators

Ribavirin #65085

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Chemical structure of Ribavirin.

Product Usage Information

Ribavirin is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.02 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 244.2 g/mol

Purity: >98%

Molecular Formula: C8H12N4O5

CAS: 36791-04-5

Solubility: Soluble in DMSO at 25 mg/ml or water at 25 mg/ml.

Background

Ribavirin is a purine ribonucleoside analogue most widely known for its broad-spectrum anti-viral properties against both RNA and DNA viruses. Ribavirin is capable of mimicking the activity of inosine, guanosine, or adenosine and has mutagenic properties that can cause the disruption of viral genome transcription and translation. The monophosphate metabolite is a competitive inhibitor of inosine monophosphate (IMP) dehydrogenase with a Ki value of 270 nM (1-3). Ribavirin multifariousness enables simultaneous manipulation of both viral and host enzymatic processes and exhibits several immunomodulatory mechanisms including key roles in the mediation of pathways such as ERK, eIF4E, MNK1, EZH2, and MAPK (4,5). Studies have shown that in vitro treatment of Middle East respiratory syndrome coronavirus (MERS-CoV) with Ribavirin and interferon-α2b reduces viral replication, making Ribavirin a compound of interest when studying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (6,7).

  1. Streeter, D.G. et al. (1973) Proc Natl Acad Sci U S A 70, 1174-8.
  2. Gilbert, B.E. and Knight, V. (1986) Antimicrob Agents Chemother 30, 201-5.
  3. Crotty, S. et al. (2000) Nat Med 6, 1375-9.
  4. Graci, J.D. and Cameron, C.E. Rev Med Virol 16, 37-48.
  5. Casaos, J. et al. (2018) Oncotarget 9, 8054-67.
  6. Falzarano, D. et al. (2013) Sci Rep 3, 1686.
  7. Wang, M. et al. (2020) Cell Res 30, 269-71.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 65085S
Product # Size Price
65085S
100 mg $ 115