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67765
RIPA-56
Activators & Inhibitors
Chemical Modulators

RIPA-56 #67765

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RIPA-56: Image 1
Chemical structure of RIPA-56.

Product Usage Information

RIPA-56 is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.13 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 221.3 g/mol
Purity >98%
Molecular Formula C13H19NO2
CAS 1956370-21-0
Solubility Soluble in DMSO at 50 mg/ml or ethanol at 50 mg/ml.

Background

RIPA-56 is a potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) kinase with an IC50 value of 13 nM, with no effect on RIP3 kinase activity at a 10 μM concentration. RIPA-56 has been shown to reduce TNFα-induced mortality and multiorgan damage in systemic inflammatory response syndrome (SIRS) (1). Blocking the activity of RIP1 kinase allows for cell survival and proliferation in the presence of death receptor ligands. In vivo studies have also shown that necroptosis can be inhibited in the testes of busulfan-induced mice by the suppression of RIP1 kinase with RIPA-56 (2). This small molecule can protect myelin structures by blocking the demyelination and inflammation of spinal cord white matter in mice experimental autoimmune encephalomyelitis (EAE)-induced models, halting the progression of multiple sclerosis (MS) (3).
  1. Ren, Y. et al. (2017) J Med Chem 60, 972-86.
  2. Xie, Y. et al. (2020) Stem Cells Dev 29, 475-87.
  3. Zhang, S. et al. (2019) Proc Natl Acad Sci U S A 116, 5675-80.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 67765S
Product # Size Price
67765S
5 mg $ 57