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STING Degrader-1

STING Degrader-1 #89847

Name: STING Degrader-1
Price: 270.00 USD
Availability: InStock

Product Information

Product Usage Information

STING Degrader-1 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 715 μL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	699.7 g/mol
Purity	98%
Molecular Formula	C₃₄H₃₃N₇O₁₀
CAS	2762552-74-7
Solubility	Soluble in DMSO at 25 mg/mL.

Background

Stimulator of interferon genes (STING) Degrader-1 is a compound known as a proteolysis-targeting chimera (PROTAC) with a DC₅₀ of 3.2 μM (1). The small molecules are heterobifunctional, consisting of two protein binding parts joined by a linker. One part of the molecule binds a protein of interest (POI), while the other part binds an E3 ubiquitin ligase, bringing the E3 ligase close to the POI for ubiquitination-coupled protein degradation (2). This complex tags the protein of interest for degradation by the proteasome, decreasing the levels of STING in a cell (3). STING protein is involved in the innate immune response through the activation of type I interferons in response to infections, and can also be linked to autoimmune disorders due to excessive activation. STING Degrader-1 is a potential therapeutic compound used when autoimmune diseases are caused by overactive STING and can lead to excessive immune responses, including chronic inflammation (1).

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not for Use in Diagnostic Procedures.

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