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Activators & Inhibitors
Chemical Modulators

Triptolide #97539

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other Image 1 - Triptolide

Chemical structure of Triptolide.

Product Usage Information

Triptolide is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.38 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 360.4 g/mol

Purity: >98%

Molecular Formula: C20H24O6

CAS: 38748-32-2

Solubility: Soluble in DMSO at 7 mg/ml.


Triptolide is an immunosuppressive and anti-inflammatory compound produced by the thunder god vine, Tripterygium wilfordii Hook F (1). Covalent binding of Triptolide to human XPB/ERCC3 inhibits its DNA-dependent ATPase activity and prevents nucleotide excision repair by the TFIIH complex (2). Triptolide has proven to be an effective synergistic therapy for inhibition of pancreatic cancer cell growth, with IC50 values of 0.01 µM and 0.02 µM in Capan-1 and Capan-2 adenocarcinoma cells, respectively (3,4). In addition to its anti-tumor activity, Triptolide has shown antiviral efficacy in HIV-1 and dengue virus via inhibition of Tat protein and COX-2, respectively (5,6).

  1. Li, F.Q. et al. (2004) J Neuroimmunol 148, 24-31.
  2. Titov, D.V. et al. (2011) Nat Chem Biol 7, 182-8.
  3. Qiao, Z. et al. (2016) Oncol Lett 11, 3527-33.
  4. Kim, S.T. et al. (2018) BMC Cancer 18, 1103.
  5. Wan, Z. and Chen, X. (2014) Retrovirology 11, 88.
  6. Liou, J.T. et al. (2008) Eur J Pharmacol 589, 288-98.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 97539S
Product # Size Price
5 mg $ 112