BAT3 Antibodies

Target Information

an ATP-dependent chaperone protein that functions as part of the BAT3 complex (minimally composed of BAG6, UBL4A and GET3), a cytosolic protein quality control complex. Maintains client proteins in a soluble state and participates to the post-translational delivery of tail-anchored (TA), type II transmembrane proteins to the endoplasmic reticulum membrane. It is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum membrane. Alternatively, it can promote the sorting of client proteins to the proteasome where they undergo degradation. Plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1 by regulating AIFM1 stability and preventing its degradation. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. Additionally interacts with CTCFL, HSPA2, EP300, NCR3, ricin A chain, and L.pneumophila proteins Lpg2160 and LegU1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.

Alternate Names

BAG cochaperone 6; BAG family molecular chaperone regulator 6; BAG-6; BAG6; BAT3; BCL2 associated athanogene 6; BCL2-associated athanogene 6; D6S52E; G3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAG6; Large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe