BAG6 Antibody #8523
- WB
Supporting Data
REACTIVITY | H M R Mk Pg |
SENSITIVITY | Endogenous |
MW (kDa) | 150 |
SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
- Pg-Pig
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
In addition to its role as a chaperone, BAG6 has also been implicated in regulating chromatin structure and gene expression. For example, BAG6 and SET1A act as binding partners for BORIS to effect changes of chromatin structure and gene expression (9). Similarly, increased expression of BAG6 induces p300-mediated acetylation of p53, which is required for DNA damage response (10). BAG6 has also been found to interact with TGF-β, and in so doing acts as a positive regulator of TGF-β1 stimulation of type 1 collagen expression (11). BAG6 also suppresses bone morphogenic protein (BMP) signaling via its interaction with and regulation of small C-terminal domain phosphatase (SCP) that dephosphorylates SMAD proteins, resulting in subsequent termination of BMP-mediated events (12).
- Hessa, T. et al. (2011) Nature 475, 394-7.
- David, R. (2011) Nat Rev Mol Cell Biol 12, 550.
- Ast, T. and Schuldiner, M. (2011) Curr Biol 21, R692-5.
- Mariappan, M. et al. (2010) Nature 466, 1120-4.
- Leznicki, P. et al. (2010) J Cell Sci 123, 2170-8.
- Minami, R. et al. (2010) J Cell Biol 190, 637-50.
- Wang, Q. et al. (2011) Mol Cell 42, 758-70.
- Claessen, J.H. and Ploegh, H.L. (2011) PLoS One 6, e28542.
- Nguyen, P. et al. (2008) Mol Cell Biol 28, 6720-9.
- Sasaki, T. et al. (2007) Genes Dev 21, 848-61.
- Kwak, J.H. et al. (2008) J Biol Chem 283, 19816-25.
- Goto, K. et al. (2011) Cell Death Dis 2, e236.
Limited Uses
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