CD133 Antibodies

Target Information

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Belongs to the prominin family. Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

4932416E19Rik; AC13; AC133; Antigen AC133; Antigen AC133 homolog; CD133; CORD12; hematopoietic stem cell antigen; hProminin; MCDR2; MSTP061; Pro; Prom; Prom-1; PROM1; Prom1; prominin 1; Prominin-1; prominin-like 1; Prominin-like protein 1; PROML1; Proml1; RP41; STGD4