FAS Antibodies

Target Information

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

AI196731; ALPS1A; APO-1; Apo-1 antigen; APO-1 cell surface antigen; APO1; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; APT1; Apt1; CD95; CD95 antigen; FAS; Fas; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas cell surface death receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; mutant tumor necrosis receptor superfamily member 6; TNF; TNF receptor superfamily member 6; Tnfr; TNFR6; TNFRSF6; Tnfrsf6; TNR6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6