IL18 Antibodies

Target Information

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Iboctadekin; IFN-gamma-inducing factor; IGIF; Igif; IL 18; Il-; IL-1 gamma; IL-18; IL-1g; IL18; Il18; IL1F4; Interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin 18; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; MGC12320