MAFB Antibodies

Target Information

Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Belongs to the bZIP family. Maf subfamily. Ubiquitous. Note: This description may include information from UniProtKB.

Alternate Names

DURS3; Kreisler maf-related leucine zipper homolog; KRML; MAF bZIP transcription factor B; Maf-B; MAFB; MAFB/Kreisler basic region/leucine zipper transcription factor; MCTO; MGC43127; Transcription factor MafB; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)