PTPRZ1 Antibodies

Target Information

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

HPTPZ; HPTPzeta; HTPZP2; phosphacan; protein tyrosine phosphatase receptor type Z1; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; PTP-ZETA; PTP18; PTPRZ; PTPRZ1; PTPRZ2; PTPZ; R-PTP-zeta; R-PTP-zeta-2; receptor-type tyrosine phosphatase beta/zeta; Receptor-type tyrosine-protein phosphatase zeta; RPTPB; RPTPbeta