TfR Antibodies

Target Information

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. Belongs to the peptidase M28 family. M28B subfamily. Note: This description may include information from UniProtKB.

Alternate Names

2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; mammary tumor virus receptor 1; Mtv; Mtvr; Mtvr-1; Mtvr1; p90; sTfR; T9; TfR; TfR1; TFRC; Tfrc; TR; transferrin receptor; transferrin receptor (p90, CD71); Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr