VDAC1 Antibodies

Target Information

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the eukaryotic mitochondrial porin family. Heart, liver and skeletal muscle. Note: This description may include information from UniProtKB.

Alternate Names

hVDAC1; MGC111064; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; PORIN; Porin 31HL; Porin 31HM; PORIN-31-HL; sperm binding protein 1a; VDAC; VDAC-1; VDAC1; voltage dependent anion channel 1; voltage-dependent anion channel 1; Voltage-dependent anion-selective channel protein 1