Akt3 Antibodies

Target Information

one of three AKT kinases of the AGC family that plays a critical role in controlling the balance between survival and apoptosis. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

AKT serine/threonine kinase 3; AKT3; DKFZp434N0250; MPPH; MPPH2; PKB gamma; PKB-GAMMA; PKBG; PRKBG; Protein kinase Akt-3; Protein kinase B gamma; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; serine threonine protein kinase, Akt-3; STK-2; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)