BIN1 Antibodies

Target Information

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro. Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle. 11 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

AMPH2; Amphiphysin II; Amphiphysin-like protein; AMPHL; BIN1; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; CNM2; DKFZp547F068; MGC10367; Myc box-dependent-interacting protein 1; SH3P9