CASP1 Antibodies

Target Information

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly. Belongs to the peptidase C14A family. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Casp; CASP-1; CASP1; Casp1; CASP1 nirs variant 1; Caspase 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); Caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; Caspase1; caspase1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; Il1; IL1B-convertase; IL1BC; Il1bc; IL1BCE; interleukin 1 beta-converting enzyme; interleukin 1-B converting enzyme; interleukin 1-beta convertase; interleukin 1, beta, convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45