CBX2 Antibodies
Target Information
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Alternate Names
CBX2; CDCA6; cell division cycle associated 6; chromobox 2; chromobox homolog 2 (Pc class homolog, Drosophila); Chromobox protein homolog 2; M33; M33 polycomb-like; MGC10561; modifier 3; Pc class homolog; SRXY5CBX2 Antibody Products
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