CD86 Antibodies

Target Information

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. Expressed by activated B-lymphocytes and monocytes. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Activation B7-2 antigen; B-lymphocyte activation antigen B7-2; B7; B7-2; B7-2 antigen; B7.2; B70; BU63; CD28 antigen ligand 2; Cd28l; Cd28l2; CD28LG2; CD86; Cd86; CD86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; Early T-cell costimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly-5; Ly-58; Ly5; Ly58; MB7; MB7-2; MGC34413; OTTMUSP00000015940; T-lymphocyte activation antigen CD86; TS/A-2