CMTM6 Antibodies

Target Information

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. Belongs to the chemokine-like factor family. Expressed in the leukocytes, placenta and testis. Note: This description may include information from UniProtKB.

Alternate Names

2810051A14Rik; AA536733; chemokine-like factor super family 6; chemokine-like factor superfamily 6; Chemokine-like factor superfamily member 6; CKLF like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain-containing protein 6; CKLF6; Cklfs; CKLFSF6; Cklfsf6; CMTM6; Cmtm6; FLJ20396; PRO2219; Q9CZ69