CNR1 Antibodies

Target Information

a Galpha-protein coupled receptor for endogenous cannabinoids. Ligands inclide anandamide, 2-AG, and phytocannabinoids such as THC. Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase, thus reducing cyclic AMP concentrations. Inhibits L-type Ca(2+) channel current. Has been reported to influence food intake, memory, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, and chronic pain. High-fat diet increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Isoform 2 and isoform 3 have altered ligand binding. Isoform 1 binds both 2-AG and anandamide, while Isoforms 2 and 3 only binds 2-AG with high affinity. Note: This description may include information from UniProtKB.

Alternate Names