eIF2-beta Antibodies

Target Information

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.

Alternate Names

DKFZp686L18198; eIF-2-beta; EIF2; eIF2-beta; EIF2B; EIF2beta; EIF2S2; eukaryotic initiation factor 2-beta; eukaryotic translation initiation factor 2 beta; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; IF2B; MGC8508; PPP1R67; protein phosphatase 1, regulatory subunit 67