eIF2 beta (F2R7D) Rabbit Monoclonal Antibody #67311
- WB
- IP
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 48 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The eIF2β subunit plays a major role in various interactions of the eIF2 trimer with other proteins. eIF2β has been shown to directly interact with other eIF factors, including eIF5, eIF2B, and eIF3 (7-9). eIF2β has also been shown to directly bind mRNA through a C-terminal zinc-finger motif (10,11). Phosphorylation of eIF2β by CK2 promotes the guanine nucleotide exchange activity of eIF2β (12,13).
- Kimball, S.R. (1999) Int J Biochem Cell Biol 31, 25-9.
- de Haro, C. et al. (1996) FASEB J 10, 1378-87.
- Kaufman, R.J. (1999) Genes Dev 13, 1211-33.
- Sheikh, M.S. and Fornace, A.J. (1999) Oncogene 18, 6121-8.
- Cheshire, J.L. et al. (1999) J Biol Chem 274, 4801-6.
- Zamanian-Daryoush, M. et al. (2000) Mol Cell Biol 20, 1278-90.
- Das, S. and Maitra, U. (2000) Mol Cell Biol 20, 3942-50.
- Asano, K. et al. (1999) EMBO J 18, 1673-88.
- Valásek, L. et al. (2002) EMBO J 21, 5886-98.
- Donahue, T.F. et al. (1988) Cell 54, 621-32.
- Laurino, J.P. et al. (1999) Mol Cell Biol 19, 173-81.
- Llorens, F. et al. (2003) Biochem J 375, 623-31.
- Llorens, F. et al. (2006) Biochem J 394, 227-36.
Alternate Names
DKFZp686L18198; eIF-2-beta; EIF2; eIF2-beta; EIF2B; EIF2beta; EIF2S2; eukaryotic initiation factor 2-beta; eukaryotic translation initiation factor 2 beta; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; IF2B; MGC8508; PPP1R67; protein phosphatase 1, regulatory subunit 67
Limited Uses
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