EPCAM Antibodies

Target Information

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. Belongs to the EPCAM family. Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. Note: This description may include information from UniProtKB.

Alternate Names

ACSTD1; Adenocarcinoma-associated antigen; carcinoma-associated antigen GA733-2; CD326; Cell surface glycoprotein Trop-1; CO-17A; CO17-1A; DIAR5; EGP; EGP-; EGP-2; Egp31; EGP314; Egp314; EGP34; EGP40; Ep-C; Ep-CAM; EpC; EpCA; EPCAM; Epcam; EpCAM1; Epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; epithelial glycoprotein 314; ESA; GA733-; GA733-2; gp4; gp40; hEGP-2; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly7; Ly74; lymphocyte antigen 74; M1S2; M4S1; Major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Tacsd1; Tacst; TACST-1; TACSTD1; Tacstd1; Trop-1 protein; TROP1; trophoblast cell surface antigen 1; Tumor-associated calcium signal transducer 1; tumor-associated calcium signal transducer 1