FLNA Antibodies

Target Information

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. Belongs to the filamin family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

ABP-280; ABPX; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; CSBS; CVD1; DKFZp434P031; Endothelial actin-binding protein; epididymis secretory sperm binding protein; FGS2; filamin 1; filamin A; filamin A, alpha; Filamin-1; Filamin-A; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; Non-muscle filamin; OPD; OPD1; OPD2; XLVD; XMVD