galectin-3 Antibodies

Target Information

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. Note: This description may include information from UniProtKB.

Alternate Names

35 kDa lectin; advanced glycation end-product receptor 3; Carbohydrate-binding protein 35; CBP 35; CBP35; epididymis secretory sperm binding protein; Gal-3; GAL3; gal3; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; galect; galectin 3; Galectin-3; GALIG; GBP; IgE-binding protein; L-3; L-31; L-34; L-34 galactoside-binding lectin; L31; Laminin-binding protein; Lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside-binding, soluble, 3; LEG3; LGALS2; LGALS3; Lgals3; Mac-; Mac-2; Mac-2 antigen; MAC2