IL27RA Antibodies

Target Information

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily. Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. Note: This description may include information from UniProtKB.

Alternate Names

class I cytokine receptor; CRL1; cytokine receptor family, class 1 (WSXWS), member 1; Cytokine receptor WSX-1; Cytokine receptor-like 1; I27RA; IL-; IL-27 receptor subunit alpha; IL-27R; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R; IL27RA; Il27ra; interleukin 27 receptor subunit alpha; interleukin 27 receptor, alpha; Interleukin-27 receptor subunit alpha; T cell cytokine receptor; T-cell cytokine receptor type 1; Tcc; TCCR; Type I T-cell cytokine receptor; WSX-; WSX-1; WSX1; Wsx1; ZcytoR1; zcytor1