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IL-27RA (E3L6U) Rabbit Monoclonal Antibody #41220

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 95, 105
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IL-27RA (E3L6U) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-27RA protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human IL-27RA protein.

    Background

    Interleukin 27 receptor α (IL-27RA or IL-27Rα), also known as T cell cytokine receptor (TCCR) and WSX-1, forms a receptor complex with gp130 to bind and enable IL-27 signaling (1,2). IL-27Rα is expressed on T cells, B cells, natural killer (NK) cells, monocytes, macrophages, dendritic cells (DCs), as well as on subsets of epithelial and endothelial cells (3). Binding of IL-27 to its receptor complex induces the activation of receptor-associated Jak1 and Jak2, which in turn phosphorylates Stat1 and Stat3 (4,5). IL-27 signaling plays an important anti-inflammatory role in chronic immune-mediated disease and infectious disease, and enhances the expression of co-inhibitory molecules LAG-3, TIM-3, PD-1, and TIGIT (6-8). Due to its immunosuppressive role in cancers, IL-27 has been identified as a target for cancer immunotherapy (9).

    Alternate Names

    class I cytokine receptor; CRL1; Cytokine receptor WSX-1; Cytokine receptor-like 1; I27RA; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R; IL27RA; interleukin 27 receptor subunit alpha; interleukin 27 receptor, alpha; Interleukin-27 receptor subunit alpha; T-cell cytokine receptor type 1; TCCR; Type I T-cell cytokine receptor; WSX-1; WSX1; ZcytoR1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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