IP3R1 Antibodies

Target Information

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. Widely expressed. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

ACV; CLA4; DKFZp313E1334; DKFZp313N1434; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; PPP1R94; protein phosphatase 1, regulatory subunit 94; SCA15; SCA16; SCA29; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor