IRF9 Antibodies

Target Information

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Belongs to the IRF family. Note: This description may include information from UniProtKB.

Alternate Names

IFN-alpha-responsive transcription factor subunit; interferon dependent positive acting transcription factor 3 gamma; Interferon regulatory factor 9; Interferon-stimulated gene factor 3 gamma; interferon-stimulated transcription factor 3, gamma (48kD); interferon-stimulated transcription factor 3, gamma 48kDa; Irf; IRF-9; IRF9; Irf9; Isgf; ISGF-3 gamma; ISGF3; ISGF3 p48 subunit; ISGF3G; Isgf3g; p48; Transcriptional regulator ISGF3 subunit gamma