LC3B Antibodies

Target Information

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Belongs to the ATG8 family. Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. Note: This description may include information from UniProtKB.

Alternate Names

1010001C15Rik; Atg; Atg8; ATG8F; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; LC3; LC3B; Map1; MAP1 light chain 3-like protein 2; MAP1A/1BLC3; MAP1A/MAP1B; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; MAP1ALC3; Map1alc3; Map1lc3; MAP1LC3B; Map1lc3b; MAP1LC3B-a; MGC118046; microtubule associated protein 1 light chain 3 beta; Microtubule-associated protein 1 light chain 3 beta; microtubule-associated proteins 1A/1B light chain 3; Microtubule-associated proteins 1A/1B light chain 3B; MLP3B