MAML1 Antibodies
Target Information
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Belongs to the mastermind family. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Note: This description may include information from UniProtKB.
Alternate Names
FLJ53540; KIAA0200; Mam-1; Mam1; MAML1; mastermind homolog; mastermind like transcriptional coactivator 1; mastermind-like 1; mastermind-like 1 (Drosophila); Mastermind-like protein 1MAML1 Antibody Products
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