Myt1 Antibodies

Target Information

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

DKFZp547K1610; FLJ20093; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT1; PMYT1; PPP1R126; protein kinase Myt1; protein kinase, membrane associated tyrosine/threonine 1; protein phosphatase 1, regulatory subunit 126