NFkB-p65 Antibodies

Target Information

a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. For example,RELA-NFkB1 and RELA-REL complexes function as transcriptional activators. NFkB complexes are held in the cytoplasm in an inactive state complexed with IkB proteins. When IkB is phosphorylated by IkB kinases (IKKs), it is degraded, allowing active NFkB complexes to translocate to the nucleus. Essential for cytokine gene expression in T-cells. RELA-RELA complexes appear to be involved in invasin-mediated activation of IL-8 expression. Four alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

avian reticuloendotheliosis viral (v-rel) oncogene homolog A; CMCU; MGC131774; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NFkB-p65; NFKB3; Nfkb3; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; OTTMUSP00000017977; p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; RELA; Rela; RELA proto-oncogene, NF-kB subunit; RELA/p65; TF65; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)); v-rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65