PPM1D Antibodies

Target Information

Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. Belongs to the PP2C family. Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

IDDGIP; JDVS; p53-induced protein phosphatase 1; PP2C-delta; PPM1D; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase Wip1; protein phosphatase, Mg2+/Mn2+ dependent 1D; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; WIP1