PRSS15 Antibodies

Target Information

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. Belongs to the peptidase S16 family. Duodenum, heart, lung and liver, but not thymus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CODASS; hLON; hLON ATP-dependent protease; LON; lon peptidase 1, mitochondrial; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONM; LONP; LONP1; MGC1498; Mitochondrial ATP-dependent protease Lon; mitochondrial lon peptidase 1; mitochondrial lon protease-like protein; PIM1; protease, serine, 15; PRSS15; Serine protease 15