RAPGEF4 Antibodies

Target Information

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 5 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.

Alternate Names

1300003D15Rik; 5730402K07Rik; 6330581N18Rik; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-G; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; CGEF2; Cgef2; Epa; EPAC; EPAC 2; Epac-2; EPAC2; Epac2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; KIAA4040; mKIAA4040; Nbla00496; OTTMUSP00000014141; putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; RAP guanine-nucleotide-exchange factor (GEF) 4; RAPGEF4; Rapgef4; RPGF4