SCN11A Antibodies

Target Information

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

FEPS3; hNaN; HSAN7; NaN; NAV1.9; Peripheral nerve sodium channel 5; PN5; SCN11A; SCN12A; SCNBA; Sensory neuron sodium channel 2; SNS-2; SNS2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium voltage-gated channel alpha subunit 11; voltage-gated sodium channel Nav1.9; Voltage-gated sodium channel subunit alpha Nav1.9