VCP Antibodies

Target Information

an ATPase enzyme present in all eukaryotes and archaebacteria. Is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Is involved in vesicle transport and fusion, and in the formation of the transitional endoplasmic reticulum (tER). tER contains ER exit sites involved in the transfer of membranes from the endoplasmic reticulum to the Golgi apparatus. Vesicle budding from the tER is an ATP-dependent process. Is part of the complex containing NPLOC4-UFD1-VCP that binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex also regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP-AMFR complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced preemptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of the stress granule (SGs) clearance process upon arsenite-induced response. Involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Belongs to the AAA ATPase family. Note: This description may include information from UniProtKB.

Alternate Names