XBP1 Antibodies

Target Information

a transcription factor that regulates the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Required for differentiation of plasma cells, immunoglobulin secretion, cardiac myogenesis hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Induces phospholipid biosynthesis and ER expansion. Contributes to VEGF-induced endothelial cell proliferation and angiogenesis in adult tissues under ischemic conditions. Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation. Promotes tumor progression by stimulating zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells. Its mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Binds to the HDAC3, BECN1, PPARG and CDH5/VE-cadherin gene promoter regions. Binds to the ER stress response element (ERSE) upon ER stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript. Belongs to the bZIP family. Note: This description may include information from UniProtKB.

Alternate Names

D11Ertd39; D11Ertd39e; Tax-responsive element-binding protein 5; tax-responsive element-binding protein 5 homolog; TREB; TREB-; TREB-5; TREB5; Treb5; X-box binding protein 1; X-box-binding protein 1; X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form; XBP-; XBP-1; XBP-1S; XBP1; XBP1 iso2; XBP1(S); XBP2