ZBP1 Antibodies

Target Information

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

2010010H03Rik; C20orf183; DAI; Dai; DLM-1; DLM1; Dlm1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of interferon regulatory factors; DNA-dependent activator of IRFs; mZaD; mZaDLM; OTTMUSP00000018050; Tumor stroma and activated macrophage protein DLM-1; Z-DNA binding protein 1; Z-DNA-binding protein 1; ZBP1; Zbp1