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52162
Acetyl-CoA Carboxylase (C83B10) Rabbit mAb (PE Conjugate)

Acetyl-CoA Carboxylase (C83B10) Rabbit mAb (PE Conjugate) #52162

This product is discontinued

Storage:

Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.

Acetyl-CoA Carboxylase (C83B10) Rabbit mAb (PE Conjugate) detects endogenous levels of all isoforms of acetyl-CoA carboxylase protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser523 of human acetyl-CoA carboxylase α1.

This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated Acetyl-CoA Carboxylase (C83B10) Rabbit mAb #3676.

Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA (1). It is the key enzyme in the biosynthesis and oxidation of fatty acids (1). In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while 280 kDa ACC2 (ACCβ) is the main isoform in oxidative tissues (1,2). However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues (1,2). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (3). ACC is a potential target of anti-obesity drugs (4,5).

  1. Castle, J.C. et al. (2009) PLoS One 4, e4369.
  2. Kreuz, S. et al. (2009) Diabetes Metab Res Rev 25, 577-86.
  3. Ha, J. et al. (1994) J. Biol. Chem. 269, 22162-22168.
  4. Abu-Elheiga, L. et al. (2001) Science 291, 2613-2616.
  5. Levert, K.L. et al. (2002) J. Biol. Chem. 277, 16347-16350.
Entrez-Gene Id
31 , 32
Swiss-Prot Acc.
Q13085 , O00763
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.

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